NanoUp just got granted a I+D+i Retos Investigación project!
We are glad being granted a "I+D+i Retos Investigación" project by the Spanish ministry of Science, Innovation and Universities (MICIIN)
The ultimate strategy to shrink porous metal-organic materials down to the sub-5-nm scale is isolation of the metal-organic polyhedra (MOP) units that define the cavities in metal-organic framework structures. In this MOP3 project, we aim to explore this strategy and use the ultrasmall size (~1 nm to 5 nm) of isolated, porous MOPs to develop: i) new adsorbents, enabled by the solubility and processability in liquids of these materials; and ii) new, soluble molecular “nanoparticles” or “nanoplatforms” that can be stoichiometrically functionalised at specific positions and/or in which the growth of inorganic clusters can be confined inside their internal cavities. We plan to synthesise multiple Rh(II)-based MOPs, and then explore them as soluble adsorbents and molecular “nanoparticles”, and as processable nanoscale building units to form membranes, composites and extended structures for applications related to Environmental Protection, Energy and Biomedicine: heavy-metal pollutant removal, gas sorption, catalysis and drug delivery.
The first part of MOP3 encompasses the design, synthesis and precise characterisation of multiple porous Rh(II)-based lantern-type or cuboctahedron-type MOPs, and the study of their post-synthetic functionalization via coordination/covalent chemistry and via controlling the growth of inorganic clusters (e.g. Pt, Pd, Au) into their internal cavities. The first part of the project is also focused on the fabrication of membranes and extended porous structures using the synthesized MOP units as processable and soluble nanoscale building units. The second part of MOP3 entails studying the newly designed MOP-based adsorbents and molecular “nanoparticles” for several applications of high socioeconomic benefit consistent with the Spanish Strategy of Science, Technology and Innovation: heavy-metal pollutant removal, gas capture, catalysis and drug delivery. As proof-of-concept, we will study their capacity to remove heavy metal ions such as As(III), As(V), Cr(VI), Hg(II), Cd(II) and Pb(II); their capacity to adsorb CO2 and to catalyse the CO2 transformation into alcohols; and their toxicity in vitro and enhancement of their therapeutic efficacy once functionalized with Pt(IV) pro-drugs.
Overall, in MOP3 we will endeavour to explore the miniaturization of porous metal-organic materials at the sub-5nm regime for developing new soluble adsorbents, composites and “nanoparticles”; using them as nanoscale building units to construct membranes and extended porous structures; and testing the resulting materials for myriad Environmental Protection, Energy and Biomedicine related applications.